University Hospital Basel
University Hospital Basel
Matthias E. Liechti is a professor for clinical pharmacology and internal medicine at the University of Basel and an attending physician at the Division of Clinical Pharmacolgoy and Toxicology of the University Hospital Basel where he also heads the psychopharmacology research group. Liechti obtained his clinical training in internal medicine at the University Hospital of Zurich and worked as postdoctoral researcher at the University Hospital of Psychiatry in Zurich and at the University of California San Diego in the Department of Psychiatry. He is now affiliated with the Department of Biomedicine and the Department of Clinical Research and he conducts preclinical and clinical research. Matthias Liechti investigates the pharmacology of psychoactive substances both in vitro and in humans. The group is best known for the work on the acute effects psychoactive substances including MDMA (ecstasy), methylphenidate (Ritalin) and LSD in humans. In experimental clinical studies Matthias Liechti mainly described the acute effects of psychoactive substances on social cognition (mood recognition, empathy, prosocial behaviour, sexual arousal), endocrine responses (steroids, oxytocin, vasopressin), but also pharmacokinetics-pharmacodynamics and pharmacogenetics. Pharmaco-fMRI studies are conducted in collaboration with the Psychiatric University Clinic. The team also characterizes the pharmacological profiles of the constantly emerging novel psychoactive substances (designer drugs) using in vitro methods. The Division is also a contributing centre to the European Drug Emergeny Network (Euro-DEN).
Lysergic acid diethylamide (LSD) is used in Switzerland in the treatment of patients both in the context of compassionate use and in clinical studies including patients with anxiety associated with life-threatening diseases...more details
Vizeli, Patrick & E. Meyer zu Schwabedissen, Henriette & Liechti, Matthias. (2018). Role of Serotonin Transporter and Receptor Gene Variations in the Acute Effects of MDMA in Healthy Subjects. ACS Chemical Neuroscience.
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