Lea J. Mertens received her M.Sc. in Cognitive and Clinical Neuroscience with a specialization in Neuropsychology from Maastricht University. During her thesis internship at the Centre for Psychedelic Research, Imperial College London she i) was coordinator of the Global Psychedelic Survey (global.psychedelicsurvey.com) and ii) wrote her Master’s thesis about functional connectivity changes after treatment with psilocybin in patients with treatment-resistant major depression, supervised by Dr. R. Carhart-Harris and Dr. M. Wall.
For her PhD she has joined the recently established Department of Molecular Neuroimaging, headed by Prof. Gerhard Gründer, at the Central Institute of Mental Health (CIMH) in Mannheim. Her main research interests lie in the therapeutic potential as well as biological and psychological mechanisms of psychoactive substances, with a particular focus on psychedelic drugs.
Psilocybin has shown promise as a treatment for depression but its therapeutic mechanisms are not properly understood. In contrast to the presumed action of antidepressants, we recently found increased right amygdala responsiveness to fearful faces one day after treatment with psilocybin in 19 patients with treatment-resistant depression (TRD), which correlated with treatment efficacy. This was interpreted as regained emotional responsiveness post-treatment. AIMS: The present study constitutes an extension to this basic activation analysis. We hypothesized changes in amygdala functional connectivity […]more details
Mertens, L. J., Wall, M. B., Roseman, L., Demetrious, L., Nutt, D. J., Carhart-Harris, R. L. (under review). Therapeutic Mechanisms of Psychedelic Drugs: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression.
Mertens, L. J., Witt, J. A., Helmstaedter, C. (2018). Affective and Behavioral Dysfunction under Antiepileptic Drugs in Epilepsy: Development of a New Drug-Sensitive Screening Tool. Epilepsy & Behavior, 83, 175 – 180. doi: 10.1016/j.yebeh.2018.03.040
Krause-Utz, A., Mertens, L. J., Renn, J. B., Lucke, P., Wöhlke, A. Z., van Schie, C., Mouthaan, J. (2018). Childhood Maltreatment, Borderline Personality Features, and Coping as Predictors of Intimate Partner Violence: A Serial Mediation Analysis. Journal of Intimate Partner Violence. doi: 10.1177/0886260518817782
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