The transformative potential of psychedelic substances may lie in their ability to disintegrate highly organized activity within the cortical networks underpinning self-related cognitive processes. By altering the processes through which the self is experienced and contemplated, these substances have the potential to catalyze lasting change to the narrative self (identity) and developmental trajectories. The present qualitative study explores first-person retrospective accounts of acute and lasting psychedelic-induced changes to the narrative self and the effects of those changes. Inductive thematic coding analysis generated four major themes: Self-Insight, Self-Attitudes, Autonomy and Connectedness each containing sub-themes. A secondary analysis deductively coded themes into a variation of the Multilevel Model of Identity Content in Context (Galliher et al., 2017). The analysis identifies and interprets the contents and processes of self-transformation elicited during and after the psychedelic experience.