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Acute effects of lysergic acid diethylamide and 3,4-methylenedioxymethamphetamine in healthy subjects and in patients during drug-assisted psychotherapy

The aim of the study was to characterize and compare the acute subjective effects of LSD and MDMA in healthy subjects and in patients with psychiatric disorders in different settings. Acute effects of LSD and MDMA were investigated  in placebo-controlled, double-blind, cross-over studies in a laboratory setting in a total of 40 and 194 healthy subjects, respectively. Acute effects of 200 mcg LSD were assessed in 11 patients suffering from anxiety associated with a life-threatening disease, treated alone within a placebo-controlled clinical trial. Additionally, acute effects of LSD (100-200 mcg) and MDMA (100-175 mg) were assessed in 11 patients with various psychiatric diagnoses treated in Swiss psychiatric practices in group Settings.

The results have shown that in healthy subjects, LSD and MDMA both acutely and dose-dependently increased ratings of feelings of openness, trust, and closeness to others. MDMA  significantly increased ratings of experience of unity after 125 mg compared with 75 mg. On the Mystical Experience Questionnaire MEQ, LSD significantly increased all scores compared with placebo after 100 and 200 mcg, whereas MDMA only increased ineffability, and positive mood in healthy subjects. In patients  LSD and MDMA both induced similar mystical-type experiences on the MEQ compared with healthy subjects.
LSD and MDMA both produced acute empathogenic effects that may be beneficial in drug-assisted psychotherapy. Preliminary findings indicate that LSD and MDMA induced largely comparable acute alterations in consciousness and mystical-type experiences in healthy subjects in an experimental setting and in psychiatric patients in different treatment settings

Yasmin Schmid

Yasmin Schmid

University Hospital Basel and University of Basel more about the speaker

Conference tickets

With your ticket you will have access to the whole conference - with keynotes, panels, round tables, posters and daylight social events. We will ask for a small extra fee for the Friday evening social program. The pre-conference workshops have to be booked separately and each workshop needs an individual ticket. By clicking on "Book now" below you also have the option to buy your workshop tickets.

*Reduced fees apply to students, cooperation partners as well as unemployed and retired individuals who have a monthly net income below 840,- €. Proof of status will be required.

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Catering service


With this ticket you can use the catering service all inclusive for three days. The service includes coffee, water, tea and fruit.


after 14 April 2019

  • Standard €250
  • Reduced €150*
  • MIND members Standard €180
  • MIND members Reduced €90



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